THIRD AGE TOTAL WAR ITA TRIAL
THIRD AGE TOTAL WAR ITA LICENSE

BNT162b2 was associated with a lower incidence and severity of systemic reactions than BNT162b1, particularly in older adults. In each of 13 groups of 15 participants, 12 participants received vaccine and 3 received placebo. ResultsДЄ total of 195 participants underwent randomization. In all groups but one, participants received two doses, with a 21-day interval between doses in one group (100 Ојg of BNT162b1), participants received one dose.

THIRD AGE TOTAL WAR ITA TRIAL

Trial groups were defined according to vaccine candidate, age of the participants, and vaccine dose level (10 Ојg, 20 Ојg, 30 Ојg, and 100 Ојg). The primary outcome was safety (e.g., local and systemic reactions and adverse events) immunogenicity was a secondary outcome. In an ongoing, placebo-controlled, observer-blinded, dose-escalation, phase 1 trial conducted in the United States, we randomly assigned healthy adults 18 to 55 years of age and those 65 to 85 years of age to receive either placebo or one of two lipid nanoparticleвЂ“formulated, nucleoside-modified RNA vaccine candidates: BNT162b1, which encodes a secreted trimerized SARS-CoV-2 receptorвЂ“binding domain or BNT162b2, which encodes a membrane-anchored SARS-CoV-2 full-length spike, stabilized in the prefusion conformation. Interim safety and immunogenicity data about the vaccine candidate BNT162b1 in younger adults have been reported previously from trials in Germany and the United States. Multiple vaccine candidates are under development, but no vaccine is currently available. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and the resulting disease, coronavirus disease 2019 (Covid-19), have spread to millions of persons worldwide. The most trusted, influential source of new medical knowledge and clinical best practices in the world.

THIRD AGE TOTAL WAR ITA LICENSE

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Third age total war ita